Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease

Murine therapeutic models for Charcot-Marie-Tooth (CMT) disease.

INTRODUCTION OR BACKGROUND Charcot-Marie-Tooth (CMT) disease represents a broad group of inherited motor and sensory neuropathies which can originate from various genetic aberrations, e.g. mutations, deletions and duplications. SOURCES OF DATA We performed a literature review on murine animal models of CMT disease with regard to experimental therapeutic approaches. Hereby, we focussed on the ...

Charcot - Marie - Tooth disease ( CMT )

Charcot-Marie-Tooth disease

Charcot-Marie-Tooth (CMT) disease is the most prevalent peripheral inherited neuropathy (1/2500 to 10 000; 2.8/10 000 in Spain), and the mean age at onset is 16 years (range 2 to 50 years, but presentation in the early infancy and as late as the 80's has been reported). Patients present with motor and sensory polyneuropathic semiology (distal lower limb weakness and atrophy, gait abnormalities ...

Charcot-Marie-Tooth disease

Charcot-Marie-Tooth (CMT) disease is the most prevalent peripheral inherited neuropathy (1/2500 to 10 000; 2.8/10 000 in Spain), and the mean age at onset is 16 years (range 2 to 50 years, but presentation in the early infancy and as late as the 80's has been reported). Patients present with motor and sensory polyneuropathic semiology (distal lower limb weakness and atrophy, gait abnormalities ...

clinical features of charcot-marie-tooth (cmt) disease

cmt disease is the most common inherited neuromuscular disorder, with its estimated prevalence being 17–40:100,000. although it is genetically a highly heterogeneous disorder, the clinical phenotype is relatively homogeneous. this is characterized by wasting and weakness of distal limb muscles, involving especially the peroneal compartment (hence the old term of peroneal muscular atrophy), usua...